L-702958

CAT: 0804-HY-106895Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106895Size:1 Each
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Description
L-702958 is a potent hERG blocker (IC50 = 14.3 nM) . L-702958 can be used for research on arrhythmia[1].
CAS Number
[136081-07-7]
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/antiarrhythmic-agent-1.html
Solubility
10 mM in DMSO
Smiles
O=C1CC2(CCN([C@H]3CC4=CC=C(C#N)C=C4CC3)CC2)OC5=C1C=C(NS(C)(=O)=O)C=C5
Molecular Formula
C25H27N3O4S
Molecular Weight
465.56
References & Citations
[1]Karczewski J, et al. Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel. Biochem Pharmacol. 2009 May 15;77 (10) :1602-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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