MSH6 Recombinant Antibody
CAT:
800-V4878SAF-100UG
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MSH6 Recombinant Antibody
- Description: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
- CAS Number: 9000-83-3
- UniProt: P52701
- Host: Rabbit
- Immunogen: A recombinant partial protein sequence (within amino acids 374-540) from the human protein was used as the immunogen for the MSH6 antibody.
- Clonality: Monoclonal
- Isotype: IgG κ
- Type: Recombinant
- Applications: ELISA, IHC-P
- Format: Purified
- Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
- Reconstitution: Aliquot the MSH6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
- Limitations: This MSH6 antibody is available for research use only.