TPO (Thyroid Peroxidase) (Thyroid Marker)

TPO (Thyroid Peroxidase) (Thyroid Marker)

• Gene Name: [TPO]
• NCBI Gene ID: 7173
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
• Other Gene Names: [TPO; TPO; MSA; TPX; TDH2A; TPO]
• Short Name: [TPO (Thyroid Peroxidase)]
• Other Product Names: [thyroid peroxidase isoform a; Thyroid peroxidase; thyroid peroxidase; thyroid peroxidase]
• NCBI GI Number: 28558982
• NCBI Accession Number: NP_000538.3
• NCBI GB Accession Number: NP_000538.3
• Uniprot Accession Number: P07202