Sarcomeric Actinin Alpha 2/ACTN2

Sarcomeric Actinin Alpha 2/ACTN2

• Gene Name: [ACTN2]
• NCBI Gene ID: 88
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
• Other Gene Names: [ACTN2; ACTN2; CMH23; CMD1AA]
• Short Name: [Sarcomeric Actinin Alpha 2/ACTN2]
• Other Product Names: [alpha-actinin-2 isoform 3; Alpha-actinin-2; alpha-actinin-2; actinin alpha 2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein]
• NCBI GI Number: 507588250
• NCBI Accession Number: NP_001265273.1
• NCBI GB Accession Number: NP_001265273.1
• Uniprot Accession Number: P35609