CD61/Integrin '3/Platelet Glycoprotein IIIa (Platelet Marker)

CD61/Integrin '3/Platelet Glycoprotein IIIa (Platelet Marker)

• Gene Name: [ITGB3]
• NCBI Gene ID: 3690
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8°C.
  Antibody without azide: store at -20 to -80°C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the V-chain (CD51) to form vitronectin receptor, or with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
• Other Gene Names: [ITGB3; ITGB3; GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; GP3A; GPIIIa]
• Short Name: [CD61/Integrin '3/Platelet Glycoprotein IIIa]
• Other Product Names: [integrin beta-3; Integrin beta-3; integrin beta-3; integrin subunit beta 3; Platelet membrane glycoprotein IIIa]
• NCBI GI Number: 47078292
• NCBI Accession Number: NP_000203.2
• NCBI GB Accession Number: NP_000203.2
• Uniprot Accession Number: P05106