Desmoglein-3 (Squamous Cell Marker)

Desmoglein-3 (Squamous Cell Marker)

• Gene Name: [DSG3]
• NCBI Gene ID: 1830
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
• Other Gene Names: [DSG3; DSG3; PVA; CDHF6; CDHF6; PVA]
• Short Name: [Desmoglein-3]
• Other Product Names: [Desmoglein-3; Desmoglein-3; desmoglein-3; desmoglein 3; 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6]
• NCBI GI Number: 239938621
• NCBI Accession Number: P32926.2
• Uniprot Accession Number: P32926