Major Vault Protein (MVP)

• Gene Name:

  [MVP]

• NCBI Gene ID:

  9961

• Reactivity:

  Human. Others not tested.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

• Other Gene Names:

  [MVP; MVP; LRP; VAULT1; LRP; MVP]

• Short Name:

  [Major Vault Protein (MVP)]

• Other Product Names:

  [major vault protein isoform 2; Major vault protein; major vault protein; major vault protein; Lung resistance-related protein]

• NCBI GI Number:

  645912958

• NCBI Accession Number:

  NP_001280133.1

• NCBI GB Accession Number:

  NM_001293204.1

• Uniprot Accession Number:

  Q14764