Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)

• Gene Name:

  [TYRP-1]

• NCBI Gene ID:

  7306

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

• Other Gene Names:

  [TYRP1; TYRP1; TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN; ; TRP-1; TRP1]

• Short Name:

  [Tyrosinase-Related Protein-1 (TYRP-1)]

• Other Product Names:

  [5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; tyrosinase related protein 1; Catalase B; Glycoprotein 75]

• NCBI GI Number:

  4507757

• NCBI Accession Number:

  NP_000541.1

• NCBI GB Accession Number:

  NM_000550.2

• Uniprot Accession Number:

  P17643