Dipentyl phthalate

• UNSPSC Description:

  Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].

• Target Antigen:

  Akt; AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/dipentyl-phthalate.html

• Purity:

  99.42

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(OCCCCC)C1=CC=CC=C1C(OCCCCC)=O

• Molecular Weight:

  306.402

• References & Citations:

  [1]Haiqiong Chen, et al. Exposure to dipentyl phthalate in utero disrupts the adrenal cortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPK phosphorylation. Environ Toxicol. 2023 May;38(5):997-1010.|[2]Bethany R Hannas, et al. Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates. Toxicol Sci. 2011 Mar;120(1):184-93.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Clinical Information:

  No Development Reported

• CAS Number:

  131-18-0