17-GMB-APA-GA

• Background:

  An analog of geldanamycin containing a maleimido moiety suitable for preparation of geldanamycin immunoconjugates (1-3). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

• Description:

  Hsp90 inhibitor

• Product Name Alternative:

  [ (3R,5S,6R,7S,10S,11S) -21-[3-[4- (2,5-dioxopyrrol-1-yl) butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1 (21),8,12,14,18-pentaen-10-yl] carbamate

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Heat Shock

• Purity:

  >98%

• Weight:

  0.001

• Format:

  Purple Solid

• Solubility:

  Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)

• Molecular Formula:

  C39H53N5O11

• Molecular Weight:

  767.9

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Mandler R., et al. (2004) Cancer Res. 64: 1460. 2. Mandler R., et al. (2002) Bioconj. Chem. 13: 786. 3. Mandler R., et al. (2000) J. Natl. Cancer Inst. 92: 1573.