Transthyretin L55P Variant Filaments

• Background:

  Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The L55P variant TTR is distinct from the other variants in that the L55P tetramer can dissociate to the monomeric amyloidogenic intermediate and form fibril precursors (7).

• Description:

  Human Recombinant Transthyretin L55P Variant Protein Filaments

• Product Name Alternative:

  Amyloid polyneuropathy Protein, Amyloidosis I Protein, ATTR Protein, Carpal tunnel syndrome 1 Protein, CTS Protein, CTS1 Protein, HEL111 Protein, HsT2651 Protein, PALB Protein, Prealbumin Protein, Prealbumin amyloidosis type I Protein, Prealbumin Thyroxine-binding Protein, TBPA Protein, Thyroxine binding prealbumin Protein, Transthyretin Protein, TTHY_HUMAN Protein,TTR Protein

• UNSPSC:

  12352202

• Gene ID:

  7276

• Swiss Prot:

  P02766

• Accession Number:

  NP_000362.1

• Cellular Locus:

  Cytoplasm | Extracellular exosome | Extracellular Region | Lysosome

• Host:

  E. coli

• Origin Species:

  Human

• Target:

  Transthyretin (TTR)

• Conjugation:

  No Tag

• Applications:

  WB, SDS-PAGE, In vivo assay, In vitro assay

• Purification Method:

  Ion-exchange Purified

• Concentration:

  Lot/batch specific. See included datasheet.

• Purity:

  >95%

• Weight:

  0.2

• Length:

  Full length

• Buffer:

  PBS pH 7.4

• Molecular Weight:

  13.876 kDa

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Additionnal Information:

  For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or the product datasheet for further information. Monomer source is catalog# SPR-451.

• References & Citations:

  1. Zeldenrust S.R., Benson M.D. (2010). Wiley. pp. 795–815. 2. Westermark P., Sletten K., Johansson B., Cornwell G.G. (1990). Proc. Natl. Acad. Sci. U.S.A. 87(7): 2843–5. 3. Andrade C. (1952). Brain. 75(3): 408–27. 4. Coelho T. (1996). Curr. Opin. Neurol. 9(5): 355–9. 5. Jacobson D.R, et. al. (1997). N. Engl. J. Med. 336(7): 466–73. 6. Li X. (2011). Mol Neurodegener. 6(1):79. 7. Lashuel H.A., Wurth C., Woo L., and Kelly J.W. (1999) Biochem. 38(41): 13560-13573.