MDM2 Antibody: FITC

• Background:

  MDM2 (Mouse Double Minute 2 homolog) is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53, controlling its stability and transcriptional activity. In the nervous system, MDM2-p53 signaling is crucial for balancing neuronal survival and apoptosis. Overactivation of p53, due to MDM2 dysfunction, can lead to excessive neuronal loss—a feature observed in neurodegenerative diseases such as Parkinson’s and ALS. MDM2 also influences synaptic plasticity and neurogenesis, suggesting broader roles in cognitive function and brain repair. Targeting the MDM2-p53 axis offers a potential neuroprotective strategy by modulating stress responses and preventing p53-mediated neurotoxicity in degenerative conditions.

• Description:

  Rabbit Anti-Human MDM2 Polyclonal

• Specifications:

  Detects ~50 kDa. ~50 kDa band is isoform 2 or 3.

• Product Name Alternative:

  MDM2, Double minute 2 protein, Hdm2, MTBP, Mouse Double Minute 2, HDMX, ACTFS, p53 Binding Protein Mdm2, Ubiquitin protein ligase E3 Mdm2, Mdm2 p53 E3 ubiquitin protein ligase homolog, MDM2BP, p53-binding protein Mdm2, Oncoprotein Mdm2, Hdm 2, E3 ubiquitin-protein ligase Mdm2, MDM 2, EC:6.3.2.-, MDM2_HUMAN, MDM2 oncogene E3 ubiquitin protein ligase, Murine Double Minute Chromosome 2, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa

• UNSPSC:

  12352203

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  4193

• Swiss Prot:

  Q00987

• Accession Number:

  NP_001138811.1

• Cellular Locus:

  Nucleus | Nucleoplasm | Cytoplasm | Nucleus | Nucleolus

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide from the mid-protein of Human MDM2 (aa. 100-200)

• Target:

  MDM2

• Clonality:

  Polyclonal

• Conjugation:

  FITC

• Tissue Specificity:

  Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.

• Type:

  Polyclonal

• Applications:

  WB | IHC

• Validated Applications:

  IHC, ICC/IF

• Field of Research:

  Cancer | Cell Cycle | p53 Pathway | Cell Signaling | Epigenetics and Nuclear Signaling | Cancer | Tumor Biomarkers | Oncoproteins

• Purification:

  Peptide Affinity Purified

• Detection Range:

  [object Object]

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.

• Weight:

  0.1

• Buffer:

  640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  Conjugated antibodies should be stored according to the product label

• Specificity:

  Detects ~50 kDa. ~50 kDa band is isoform 2 or 3.

• Species:

  Human | Mouse | Rat

• CAS Number:

  9007-83-4

• Location:

  Nucleus | Nucleoplasm | Cytoplasm | Nucleus | Nucleolus

• Immunogen Species:

  Human