Erk1/2 Antibody

• Background:

  Extracellular signal-regulated kinases 1 and 2 (Erk1/2) are central components of the MAPK signaling cascade, orchestrating cellular responses to growth factors, stress, and synaptic activity. In the nervous system, Erk1/2 regulate neuronal differentiation, synaptic plasticity, and memory formation. Dysregulation of Erk1/2 signaling has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease. Aberrant Erk1/2 activation can lead to chronic neuroinflammation, oxidative stress, and tau hyperphosphorylation—hallmarks of neurodegeneration. Conversely, controlled Erk1/2 signaling supports neuroprotection, axonal regeneration, and cognitive resilience. This dual role positions Erk1/2 as both a biomarker and a therapeutic target in neurodegenerative research. As precision medicine advances, modulating Erk1/2 activity offers a promising strategy to restore neuronal function and delay disease progression.

• Description:

  Rabbit Anti-Rat Erk1/2 Polyclonal

• Specifications:

  Detects ~44kda (ERK1) and ~42kDa (ERK2).

• Product Name Alternative:

  ERK1, ERK2, ERT1, ERT2, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, MAPK3, p38, p40, p41, p41mapk, p42 MAPK, p44 ERK1, p44 MAPK, PRKM1, PRKM2, PRKM3

• UNSPSC:

  12352203

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  50689

• Swiss Prot:

  P21708

• Accession Number:

  NP_059043.1

• Cellular Locus:

  Cytoplasm | Nucleus

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat, Bovine, Sheep, Chicken, Drosophila, Xenopus

• Immunogen:

  A 35 residue synthetic peptide, corresponding to Rat Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH.

• Target:

  ERK1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal

• Applications:

  WB | IHC | ICC/IF | FCM

• Validated Applications:

  WB, IHC, ICC/IF, FCM

• Field of Research:

  Cell Signaling | Post-translational Modifications | Phosphorylation | Neuroscience | Neurodegeneration | Alzheimer's Disease

• Purification:

  Peptide Affinity Purified

• Detection Range:

  A 1:1000 dilution of SPC-120 was sufficient for detection of ERK1/2 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000), IHC (1:100), ICC/IF (1:100), FCM (1:100) ; optimal dilutions for assays should be determined by the user.

• Weight:

  0.012

• Buffer:

  PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Boulton TG. et al. (1991) Biochemistry. 30 (1) :278-86. 2. Yoon S., and Seger R. (2006) Growth Factors 24:21-44. 3. Wolf G. (2005) Antioxid Redox Signal 7:1337-1345. 4. Chuerland D., Marmor G., Shainskaya A. and Seger R. (2008) J Biol Chem. Epub: http://www.jbc.org/cgi/doi/10.1074/jbc.M709030200 5. Zhuang S., and Schnellmann R.G. (2006) J Pharmacol Exp Ther 319:991-997.

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  -20ºC

• Specificity:

  Detects ~44kda (ERK1) and ~42kDa (ERK2) .

• Species:

  Human | Mouse | Rat | Bovine | Sheep | Chicken | Fruit Fly (Drosophila melanogaster) | African clawed frog (Xenopus laevis)

• CAS Number:

  9007-83-4

• Location:

  Cytoplasm | Nucleus

• Immunogen Species:

  Rat