GABA-A Receptor Alpha 4 Antibody: PerCP
CAT:
400-SMC-489D-PCP
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GABA-A Receptor Alpha 4 Antibody: PerCP
- Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). GABA-A Receptor Alpha 4 is associated with epilepsy (3), and research suggests that alterations in GABA- A Receptors subtypes may be involved in the resistance to antiepileptic drugs (4).
- Description: Mouse Anti-Rat GABA-A Receptor Alpha4 Monoclonal IgG1
- Specifications: Detects ~60kDa. Does not cross-react with other GABA-A-Receptor Alpha subunits.
- Product Name Alternative: GABA A receptor subunit alpha 4 Antibody, GABRA4 Antibody, Gamma aminobutyric acid A receptor Alpha 4 Antibody
- Synonyms: GABA-A Receptor Alpha 4 Antibody, Clone N398A/34: PerCP
- CAS Number: 9007-83-4
- UNSPSC: 12352203
- Gene ID: 140675
- Swiss Prot: P28471
- Accession Number: NP_542154.3
- Cellular Locus: Cell Junction | Synapse | Postsynaptic Cell Membrane | Cell Membrane
- Host: Mouse
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4
- Target: GABA A Receptor
- Clonality: Monoclonal
- Isotype: IgG1
- Clone: N398A/34 (Formerly sold as S398A-34)
- Conjugation: PerCP
- Validated Applications: WB, IHC, ICC/IF, ELISA
- Purification: Protein G Purified
- Limit Of Detection: A 1:100 dilution of SMC-489 was sufficient for detection of GABA-A R, Alpha4 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Concentration: 1 mg/ml
- Dilution: WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
- Weight: 0.1
- Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602. 3. Grabenstatter H.L., et al. (2014) Epilepsia. 55(11): 1826-1833. 4. Bethmann K., Fritschy J.M., Brandt C., Loscher W. (2008) Neurbiol Dis. 31(2): 169-187.