N-Acetylgalactosaminyltransferase 1

CAT:

804-HY-E70290-03

Size:

20 µg

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UNSPSC Description: N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3[1].
Target Antigen: Endogenous Metabolite; Wnt; β-catenin
Type: Enzyme
Related Pathways: Metabolic Enzyme/Protease;Stem Cell/Wnt
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/n-acetylgalactosaminyltransferase-1.html
Solubility: 10 mM in DMSO
Smiles: [N-Acetylgalactosaminyltransferase 1]
References & Citations: [1]Zhang J, et al. GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway. Int J Biol Sci. 2022 Oct 17;18(16):6068-6083.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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