A-1331852

CAT: 0804-HY-19741-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19741-01Size:5 mg
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Description
A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
CAS Number
[1430844-80-6]
UNSPSC
12352005
Hazard Statement
H312, H319
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-1331852.html
Purity
99.93
Solubility
DMSO : ≥ 50 mg/mL|Ethanol : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=NC(N2CC3=C(C=CC=C3C(NC4=NC5=CC=CC=C5S4)=O)CC2)=CC=C1C6=C(C)N(CC7(C8)CC9CC8CC(C9)C7)N=C6)O
Molecular Formula
C38H38N6O3S
Molecular Weight
658.81
Precautions
H312, H319
References & Citations
[1]Leverson JD, et al. Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. Sci Transl Med. 2015 Mar 18;7 (279) :279ra40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-W; Bcl-xL; Mcl-1

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