Deoxycholic acid

• UNSPSC Description:

  Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].

• Target Antigen:

  Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Deoxycholic_acid.html

• Purity:

  99.82

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C)

• Smiles:

  C[C@@]1([C@@]2([H])[C@H](C)CCC(O)=O)[C@](CC2)([H])[C@@](CC[C@@]3([H])[C@@]4(CC[C@@H](O)C3)C)([H])[C@]4([H])C[C@@H]1O

• Molecular Weight:

  392.57

• References & Citations:

  [1]Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.|[2]Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.Aquaculture. 2023 Sep 18, 740123.|Cancer Cell Int. 2019 Jan 31;19:24.|Cell Death Discov. 2020 Jul 6;6:56.|Cell Res. 2019 Mar;29(3):193-205. |Drug Metab Dispos. 2021 May;49(5):369-378.|Int J Biol Macromol. 2024 May;266(Pt 1):130939.|J Invest Dermatol. 19 November 2021.|Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.|Microbiome. 2019 Mar 20;7(1):43. |Nature. 2024 Dec 18.|R Soc Open Sci. 2020 Jul 8;7(7):200635.|Nat Cell Biol. 2018 Oct;20(10):1145-1158.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  83-44-3