Mouse Granzyme B (Recombinant)

• Description:

  Mouse Granzyme B_x000D_ Catalog number: B2010364_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Volume/Weight: 10 ug_x000D_ pH: 7.4 upon reconstitution_x000D_ Supplied as: Lyophilized Powder_x000D_ Appearance: Powder_x000D_ Applications: highly pure Mouse Granzyme B expressed in CHO. This protein acts as a protein that plays essential roles in apoptosis and is involved in inducing inflammation by stimulating cytokine release and iextracellular matrix remodeling._x000D_ Storage: -20C_x000D_ Keywords: rMuGranzyme B; CTLA-1; CCP1; Fragmentin-2; Gzmb_x000D_ Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Larimer BM, Wehrenberg-Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K,_x000D_ Boland G, Mahmood U. Granzyme B PET Imaging as a Predictive Biomarker of_x000D_ Immunotherapy Response. Cancer Res. 2017 May 1;77(9):2318-2327._x000D_ _x000D_ 2: Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ._x000D_ Granzyme B and perforin are important for regulatory T cell-mediated suppression_x000D_ of tumor clearance. Immunity. 2007 Oct;27(4):635-46._x000D_ _x000D_ 3: Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, Shen_x000D_ L, Han W, Shen L, Ding J, Shao F. Granzyme A from cytotoxic lymphocytes cleaves_x000D_ GSDMB to trigger pyroptosis in target cells. Science. 2020 May_x000D_ 29;368(6494):eaaz7548._x000D_ _x000D_ 4: Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok_x000D_ TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Gasdermin E suppresses_x000D_ tumour growth by activating anti-tumour immunity. Nature. 2020_x000D_ Mar;579(7799):415-420._x000D_ _x000D_ 5: Capaccione KM, Doubrovin M, Bhatt N, Mintz A, Molotkov A. Granzyme B PET_x000D_ Imaging of the Innate Immune Response. Molecules. 2020 Jul 7;25(13):3102._x000D_ _x000D_ 6: Hudson WH, Gensheimer J, Hashimoto M, Wieland A, Valanparambil RM, Li P, Lin_x000D_ JX, Konieczny BT, Im SJ, Freeman GJ, Leonard WJ, Kissick HT, Ahmed R._x000D_ Proliferating Transitory T Cells with an Effector-like Transcriptional Signature_x000D_ Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic_x000D_ Infection. Immunity. 2019 Dec 17;51(6):1043-1058.e4._x000D_ _x000D_ 7: Sutton VR, Andoniou C, Leeming MG, House CM, Watt SV, Verschoor S, Ciccone A,_x000D_ Voskoboinik I, Degli-Esposti M, Trapani JA. Differential cleavage of viral_x000D_ polypeptides by allotypic variants of granzyme B skews immunity to mouse_x000D_ cytomegalovirus. Biochim Biophys Acta Proteins Proteom. 2020 Sep;1868(9):140457._x000D_ _x000D_ 8: Qian Q, Chowdhury BP, Sun Z, Lenberg J, Alam R, Vivier E, Gorska MM. Maternal_x000D_ diesel particle exposure promotes offspring asthma through NK cell-derived_x000D_ granzyme B. J Clin Invest. 2020 Aug 3;130(8):4133-4151._x000D_ _x000D_ 9: Galassi C, Manic G, Musella M, Sistigu A, Vitale I. Assessment of IFN-γ and_x000D_ granzyme-B production by in "sitro" technology. Methods Enzymol._x000D_ 2020;631:391-414._x000D_ 10: Casciola-Rosen L, Garcia-Calvo M, Bull HG, Becker JW, Hines T, Thornberry_x000D_ NA, Rosen A. Mouse and human granzyme B have distinct tetrapeptide specificities_x000D_ and abilities to recruit the bid pathway. J Biol Chem. 2007 Feb_x000D_ 16;282(7):4545-4552. _x000D_ _x000D_ Products Related to Mouse Granzyme B : Proteins

• Short Description:

  Catalog Number: B2010364 (10 ug)_x000D_ Mouse Granzyme B is a high quality research product used as highly pure Mouse Granzyme B expressed in CHO. This protein acts as a protein that plays essential roles in apoptosis and is involved in inducing inflammation by stimulating cytokine release and iextracellular matrix remodeling. Custom bulk orders of this product are available upon request.

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3