Mouse Granzyme B (Recombinant)

• Description:

  Mouse Granzyme B_x000D_ Catalog number: B2010364_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Volume/Weight: 10 ug_x000D_ pH: 7.4 upon reconstitution_x000D_ Supplied as: Lyophilized Powder_x000D_ Appearance: Powder_x000D_ Applications: highly pure Mouse Granzyme B expressed in CHO. This protein acts as a protein that plays essential roles in apoptosis and is involved in inducing inflammation by stimulating cytokine release and iextracellular matrix remodeling._x000D_ Storage: -20C_x000D_ Keywords: rMuGranzyme B; CTLA-1; CCP1; Fragmentin-2; Gzmb_x000D_ Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Larimer BM, Wehrenberg-Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K,_x000D_ Boland G, Mahmood U. Granzyme B PET Imaging as a Predictive Biomarker of_x000D_ Immunotherapy Response. Cancer Res. 2017 May 1;77(9):2318-2327._x000D_ _x000D_ 2: Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ._x000D_ Granzyme B and perforin are important for regulatory T cell-mediated suppression_x000D_ of tumor clearance. Immunity. 2007 Oct;27(4):635-46._x000D_ _x000D_ 3: Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, Shen_x000D_ L, Han W, Shen L, Ding J, Shao F. Granzyme A from cytotoxic lymphocytes cleaves_x000D_ GSDMB to trigger pyroptosis in target cells. Science. 2020 May_x000D_ 29;368(6494):eaaz7548._x000D_ _x000D_ 4: Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok_x000D_ TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Gasdermin E suppresses_x000D_ tumour growth by activating anti-tumour immunity. Nature. 2020_x000D_ Mar;579(7799):415-420._x000D_ _x000D_ 5: Capaccione KM, Doubrovin M, Bhatt N, Mintz A, Molotkov A. Granzyme B PET_x000D_ Imaging of the Innate Immune Response. Molecules. 2020 Jul 7;25(13):3102._x000D_ _x000D_ 6: Hudson WH, Gensheimer J, Hashimoto M, Wieland A, Valanparambil RM, Li P, Lin_x000D_ JX, Konieczny BT, Im SJ, Freeman GJ, Leonard WJ, Kissick HT, Ahmed R._x000D_ Proliferating Transitory T Cells with an Effector-like Transcriptional Signature_x000D_ Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic_x000D_ Infection. Immunity. 2019 Dec 17;51(6):1043-1058.e4._x000D_ _x000D_ 7: Sutton VR, Andoniou C, Leeming MG, House CM, Watt SV, Verschoor S, Ciccone A,_x000D_ Voskoboinik I, Degli-Esposti M, Trapani JA. Differential cleavage of viral_x000D_ polypeptides by allotypic variants of granzyme B skews immunity to mouse_x000D_ cytomegalovirus. Biochim Biophys Acta Proteins Proteom. 2020 Sep;1868(9):140457._x000D_ _x000D_ 8: Qian Q, Chowdhury BP, Sun Z, Lenberg J, Alam R, Vivier E, Gorska MM. Maternal_x000D_ diesel particle exposure promotes offspring asthma through NK cell-derived_x000D_ granzyme B. J Clin Invest. 2020 Aug 3;130(8):4133-4151._x000D_ _x000D_ 9: Galassi C, Manic G, Musella M, Sistigu A, Vitale I. Assessment of IFN-Œ≥ and_x000D_ granzyme-B production by in "sitro" technology. Methods Enzymol._x000D_ 2020;631:391-414._x000D_ 10: Casciola-Rosen L, Garcia-Calvo M, Bull HG, Becker JW, Hines T, Thornberry_x000D_ NA, Rosen A. Mouse and human granzyme B have distinct tetrapeptide specificities_x000D_ and abilities to recruit the bid pathway. J Biol Chem. 2007 Feb_x000D_ 16;282(7):4545-4552. _x000D_ _x000D_ Products Related to Mouse Granzyme B : Proteins

• Short Description:

  Catalog Number: B2010364 (10 ug)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3