Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3]

• Background:

  CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1) . This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

• Abbreviation:

  PD-L1

• Gene ID:

  29126

• UniProt:

  Q9NZQ7

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant Human PD-L1 protein

• Target:

  B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; B7 homolog 1; B7-H; B7-H1; Programmed cell death ligand 1

• Clonality:

  Monoclonal

• Clone:

  29E.2A3

• Conjugation:

  Unconjugated

• Applications:

  FCM

• Field of Research:

  Cancer Biomarkers; Costimulatory Molecules; Immunology

• Purification:

  >98%, Protein A/G purified

• Concentration:

  ≥ 1 mg/mL

• Dilution:

  66

• Buffer:

  Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

• Recommended Usage:

  6

• Isotype:

  Mouse IgG2b, κ