CD80-IN-3

• UNSPSC Description:

  CD80-IN-3, a potent CD80 inhibitor, inhibits CD80/CD28 interaction with an EC50 of 630 nM and a Kd of 125 nM.

• Target Antigen:

  CD28

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cd80-in-3.html

• Purity:

  98.08

• Solubility:

  DMSO : 35.71 mg/mL (ultrasonic)

• Smiles:

  FC1=C(NC=C2C3=NN(C4=CC=C(C(O)=O)C=C4)C2=O)C3=CC=C1

• Molecular Weight:

  323.28

• References & Citations:

  [1]Huxley P, et al. High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy. Chem Biol. 2004 Dec;11(12):1651-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  486449-65-4