Thermolysin, Bacillus thermoproteolyticus rokko

• UNSPSC Description:

  Thermolysin, Bacillus thermoproteolyticus rokko (EC 3.4.24.27) (TML) is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues[1].Optimal pH: 8.0. Considerably stable from pH 5 to 9.5. Optimal temperature : 70 °C

• Target Antigen:

  Endogenous Metabolite

• Type:

  Enzyme

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/thermolysin-bacillus-thermoproteolyticus-rokko.html

• Solubility:

  H2O : 1.96 mg/mL (adjust pH to 3 with HCl)

• Smiles:

  [Thermolysin]

• References & Citations:

  [1]Bertusvan den Burg, et al. Chapter 111 - Thermolysin and Related Bacillus Metallopeptidases. |[2]Mu-Forster C, et al. Surface localization of zein storage proteins in starch granules from maize endosperm. Proteolytic removal by thermolysin and in vitro cross-linking of granule-associated polypeptides. Plant Physiol. 1998 Apr;116(4):1563-71. |[3]Di Bernardini R, et al. Isolation, purification and characterization of antioxidant peptidic fractions from a bovine liver sarcoplasmic protein thermolysin hydrolyzate. Peptides. 2011 Feb;32(2):388-400. |[4]Fujita H, et al: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 1999 Oct 15;44(1-2):123-7. |[5]Ke Q, et al. Safety evaluation of a thermolysin enzyme produced from Geobacillus stearothermophilus. Food Chem Toxicol. 2013 Sep;59:541-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20°C for 2 years

• Clinical Information:

  No Development Reported

• CAS Number:

  9073-78-3