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Recombinant Human Alkaline Phosphatase/ALPI Protein (His Tag)

CAT: 0763-PKSH030690Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH030690Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ALPI encodes for intestinal phosphatase alkaline; a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders.
Synonyms
IAP
UniProt
P09923
Accession Number
P09923
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Asp 503
Applications
Enzyme
Field of Research
Signal Transduction; Tags & Cell Markers; Cell biology; Cancer; immunology; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl phosphate (4-MUP) . The specific activity is > 1000 pmoles/min/μg.
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
54.0 kDa
Observed Molecular Weight
66 kDa
Species
Human

UniProtKB · P09923

Intestinal-type alkaline phosphatase

PPBI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09923
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALPI
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IAP, Intestinal alkaline phosphatase
EC number
3.1.3.1
Processing
Precursor
Secondary accessions
B2R7Y4, Q53S80, Q9UBV5, Q9UCL2
Protein keywords

Ligand

CalciumMagnesiumMetal-bindingZinc

Cellular component

Cell membraneMembrane

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinGPI-anchorLipoprotein

Molecular function

Hydrolase

Domain

Signal
Product Datasheet
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