BX517

• UNSPSC Description:

  BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.

• Target Antigen:

  PDK-1

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BX517.html

• Smiles:

  NC(NC1=CC=C(NC(/C2=C(C)\C3=CC=CN3)=O)C2=C1)=O

• Molecular Weight:

  282.30

• References & Citations:

  [1]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25.|[2]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  850717-64-5