CCP peptide (TFA)

CCP peptide (TFA)

• UNSPSC Description: CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA)[1][2].
• Target Antigen: Others
• Type: Peptides
• Related Pathways: Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ccp-peptide-tfa.html
• Purity: 97.83
• Solubility: H2O : 5 mg/mL (ultrasonic)
• Smiles: O=C(N[C@H]1CC2=CN=CN2)[C@@H](NC([C@@H](NC([C@H](CC3=CN=CN3)N)=O)CCC(N)=O)=O)CSSC[C@@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CO)=O)=O)CO)=O)CCCNC(N)=N)=O)=O)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCNC(N)=O)NC([C@]([H])([C@@H](C)O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC1=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
• Molecular Weight: 2455.49
• References & Citations: [1] Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7(2):189-94.|[2]Söderlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33(3):185-8.|[3]Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43(1):155-63.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported