UbcH5c Conjugating Enzyme

• Description:

  UbcH5c Conjugating Enzyme_x000D_ Catalog number: B2019682_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 ug_x000D_ Molecular Weight or Concentration: 17 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: UbcH5c Conjugating Enzyme_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Qi S, Guan X, Zhang J, Yu D, Yu X, Li Q, Yin W, Cheng XD, Zhang W, Qin JJ. Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis Mol Cancer. 2022 Mar 10;21(1):70._x000D_ 2: Zhou Y, Chen R, Luo X, Zhang WD, Qin JJ. The E2 ubiquitin-conjugating enzyme UbcH5c: an emerging target in cancer and immune disorders Drug Discov Today. 2020 Sep 16:S1359-6446(20)30369-X._x000D_ 3: Wu F, Zhu J, Li H, Zhu L. Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c Acta Pharm Sin B. 2017 May;7(3):390-394._x000D_ 4: Chen H, Wu G, Gao S, Guo R, Zhao Z, Yuan H, Liu S, Wu J, Lu X, Yuan X, Yu Z, Zu X, Xie N, Yang N, Hu Z, Sun Q, Zhang W. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives J Med Chem. 2017 Aug 24;60(16):6828-6852._x000D_ 5: Hu Q, Zhao D, Cui G, Bhandari J, Thompson JR, Botuyan MV, Mer G. Mechanisms of RNF168 nucleosome recognition and ubiquitylation Mol Cell. 2024 Mar 7;84(5):839-853.e12._x000D_ 6: Wu K, DeVita RJ, Pan ZQ. Monoubiquitination empowers ubiquitin chain elongation J Biol Chem. 2024 Mar;300(3):105753._x000D_ 7: Ranathunga DTS, Torabifard H. Histone tail electrostatics modulate E2-E3 enzyme dynamics: a gateway to regulate ubiquitination machinery Phys Chem Chem Phys. 2023 Jan 27;25(4):3361-3374._x000D_ 8: Sakasai R, Matsui T, Sunatani Y, Iwabuchi K. UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks Biochem Biophys Res Commun. 2023 Aug 6;668:42-48._x000D_ 9: Ray P, Nancarrow DJ, Ferrer-Torres D, Wang Z, San Martinho M, Hinton T, Wu JH, Wu A, Turgeon DK, Hammer MA, Dame MK, Lawrence TS, O'Brien PJ, Spence JR, Beer DG, Ray D. UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma Cell Mol Gastroenterol Hepatol. 2022;13(1):129-149._x000D_ 10: Mittal MK, Singh K, Misra S, Chaudhuri G. SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination J Biol Chem. 2011 Jan 7;286(1):469-79. _x000D_ _x000D_ Products Related to UbcH5c Conjugating Enzyme can be found at Proteins

• Short Description:

  Catalog Number: B2019682 (50 ug)_x000D_ UbcH5c, or Ubiquitin-conjugating enzyme E2 H5c, is part of the E2 ubiquitin-conjugating enzyme family. It plays a vital role in the ubiquitin-proteasome system, tagging proteins for degradation and regulating cellular processes. UbcH5c is involved in ubiquitination, substrate specificity, and interacts with E3 ligases, making it significant in protein regulation. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5