(-) -Aspartic acid

• Description :

  (-) -Aspartic acid is a pyroptosis inhibitor. (-) -Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system[5].

• Product Name Alternative :

  (R) -Aspartic acid; D- (-) -Aspartic acid

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Pyroptosis

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/_-_-Aspartic_acid.html

• Purity :

  98.0

• Solubility :

  DMSO : < 1 mg/mL|H2O : 66.67 mg/mL (ultrasonic; adjust pH to 7 with 1M NaOH)

• Smiles :

  N[C@@H](C(O)=O)CC(O)=O

• Molecular Formula :

  C4H7NO4

• Molecular Weight :

  133.10

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Xuechun Du, et al. D-aspartic acid protects against gingival fbroblasts infammation by suppressing pyroptosis. Mol Biol Rep. 2022 Jul;49 (7) :5821-5829.|[2]Di Nisio A, et al. D-Aspartic acid stimulates steroidogenesis through the delay of LH receptor internalization in a mammalian Leydig cell line. J Endocrinol Invest. 2016 Feb;39 (2) :207-213. |[3]D'Aniello A, et al. Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sci. 1996;59 (2) :97-104. |[4]D'Aniello A, et al. Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. FASEB J. 2000 Apr;14 (5) :699-714. |[5]D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53 (2) :215-34.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [1783-96-6]