Sodium Salicylate

• UNSPSC Description:

  Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1]. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle[4].

• Target Antigen:

  Apoptosis; Autophagy; COX; Endogenous Metabolite; NF-κB; Ribosomal S6 Kinase (RSK)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Autophagy;Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Sodium-Salicylate.html

• Purity:

  99.93

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL

• Smiles:

  O=C(O[Na])C1=CC=CC=C1O

• Molecular Weight:

  160.104

• References & Citations:

  [1]Mitchell JA, et al. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997 Jun;51(6):907-12.|[2]Nixon M, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012 Apr;61(4):790-6.|[3]Dongmei Bai, et al. Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation. Cancer Lett. 2020 Oct 8;S0304-3835(20)30506-1.|[4]Juhyun Oh, et al. Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY). 2016 Nov; 8(11): 2871–2884.Cancer Lett. 2021 Jan 1;496:127-133.|Commun Biol. 2024 Oct 18;7(1):1346.|J Orthop Surg Res. 2023 Dec 15;18(1):967.|Biopharm Drug Dispos. 2022 Oct 4.|bioRxiv. 2023 Jun 3.|Food Chem. 2022: 134807.|Katedra farmakologie a toxikologie. 2020 Jul.|Plant Cell. 2022 Aug 16;koac255.|PLoS Biol. 2024 June 27.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature, keep dry and cool

• Clinical Information:

  Launched

• CAS Number:

  54-21-7