Caspase 3 Apopain Substrate

• Description:

  Caspase 3 Apopain Substrate_x000D_ Catalog number: B2012959_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 2.5 mg_x000D_ Molecular Weight or Concentration: N/A_x000D_ Supplied as: Lyophilized Powder_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: -20°C_x000D_ Keywords: N-acetyl-asp-glu-val-asp-7-amino-4-trifluoromethyl coumarin, Ac-DEVD-7-AFC_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Crowley LC, Waterhouse NJ. Detecting Cleaved Caspase-3 in Apoptotic Cells by Flow Cytometry Cold Spring Harb Protoc. 2016 Nov 1;2016(11)._x000D_ 2: Choudhary GS, Al-Harbi S, Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis Methods Mol Biol. 2015;1219:1-9._x000D_ 3: Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling ACS Chem Biol. 2021 Nov 19;16(11):2280-2296._x000D_ 4: Xu WF, Zhang Q, Ding CJ, Sun HY, Che Y, Huang H, Wang Y, Wu JW, Hao HP, Cao LJ. Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure Acta Pharmacol Sin. 2021 Jan;42(1):68-76._x000D_ 5: Beroske L, Van den Wyngaert T, Stroobants S, Van der Veken P, Elvas F. Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers Int J Mol Sci. 2021 Apr 11;22(8):3948._x000D_ 6: Datta D, McClendon CL, Jacobson MP, Wells JA. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3 J Biol Chem. 2013 Apr 5;288(14):9971-9981._x000D_ 7: McKenzie BA, Fernandes JP, Doan MAL, Schmitt LM, Branton WG, Power C. Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis J Neuroinflammation. 2020 Aug 29;17(1):253._x000D_ 8: Man N, Tan Y, Sun XJ, Liu F, Cheng G, Greenblatt SM, Martinez C, Karl DL, Ando K, Sun M, Hou D, Chen B, Xu M, Yang FC, Chen Z, Chen S, Nimer SD, Wang L. Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner Blood. 2017 May 18;129(20):2782-2792._x000D_ 9: Yao L, Swartz P, Hamilton PT, Clark AC. Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3 Biosci Rep. 2021 Jan 29;41(1):BSR20203495._x000D_ 10: Ruan J, Gao S, Yang J, Li H, Huang H, Zheng X. WT1 protein is cleaved by caspase-3 in apoptotic leukemic cells Leuk Lymphoma. 2018 Jan;59(1):162-170. _x000D_ _x000D_ Products Related to Caspase 3 Apopain Substrate can be found at Substrates

• Short Description:

  Catalog Number: B2012959 (2.5 mg)_x000D_ Caspase 3 Apopain Substrate is a high quality fluorogenic CED-related caspase substrate. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5