Basic FGF (FGF2), Murine

• Description:

  GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Murine Fibroblast Growth Factor 2Fibroblast Growth Factor-basicbFGF, FGF-2basic FGFFGF2 is a member of the Fibroblast Growth Factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) .Formulation: Sterile filtered white lyophilized powder. Purified and tested for use in cell culture.Sequence: MPALPEDGGA AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV DGVREKSDPH VKLQLQAEER GVVSIKGVCA NRYLAMKEDG RLLASKCVTE ECFFFERLES NNYNTYRSRK YSSWYVALKR TGQYKLGSKT GPGQKAILFL PMSAKSMW: ~16.5 kDa (146 amino acids) Purity: >98% by SDS-PAGE and HPLC analysesBiological Activity: Fully biologically active when compared to standard. The ED50as determined by a cell proliferation assay using BALB/c 3T3 cells is less than 1.0 ng/ml, corresponding to a specific activity of >1.0 x 106IU/mg.Accession Number:P15655MGI ID:95516Source:Escherichia coli

• Molecular Weight:

  ~16.2 kDa

• Storage Conditions:

  Store desiccated at -20°C.