SARS-CoV-2 (COVID-19) ORF3a Antibody

• Background:

  Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . SARS-CoV-2 virus proteins include structural proteins, non-structural proteins and accessory factors. The structure of SARS-CoV-2 consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. SARS-CoV-2 non-structural protein is ORF1ab that consists of 16 proteins (nsp1-nsp16), while accessory factors include ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10. ORF3a forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. It up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. It induces apoptosis in cell culture and downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination (3) .

• NCBI Gene ID:

  43740569

• Swiss Prot:

  P0DTC3

• Accession Number:

  P0DTC3

• Host:

  Rabbit

• Reactivity:

  Virus

• Immunogen:

  9275

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  SARS-CoV-2 (COVID-19) ORF3a Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Buffer:

  SARS-CoV-2 (COVID-19) ORF3a antibody is supplied in PBS containing 0.02% sodium azide.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SARS-CoV-2 (COVID-19) ORF3a antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  ORF3a

• NCBI Official Name:

  ORF3a protein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Background Reference 01:

  Gorbalenya. bioRxiv: 2020.

• Background Reference 02:

  Hui et al. Int J Infect Dis. 2020;91:264-266.

• Background Reference 03:

  Lu et al. PNAS USA. 2006; 103:12540-12545.

• Other Product Names:

  ORF3a protein, Accessory protein 3a, Protein 3a, Protein U274, Protein X1, ORF3a

• Tested Applications:

  ELISA, IHC

• Protein ID:

  1835921851

• Physical Properties:

  Liquid