H3f3b Antibody (C-Term) [APR33341G]

• Synonyms:

  Histone H33, H3f3a, H33a

• Gene Name:

  H3-3a {ECO:0000250|UniProtKB:P84243}

• Gene ID:

  15078;15081

• UniProt:

  P84244

• Chromosomal Location:

  Nucleus. Chromosome.

• Applications:

  WB

• Dilution:

  WB--1:2000 WB--1:8000

• Function:

  Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

• Molecular Weight:

  15328

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality H3f3b Antibody (C-Term) [APR33341G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=15078;15081

• Uniprot URL:

  https://www.uniprot.org/uniprot/P84244