FXYD1 Antibody (C-term) [APR32909G]

• Background:

  Tissue Location: Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis

• Synonyms:

  Phospholemman, FXYD domain-containing ion transport regulator 1, FXYD1, PLM

• Gene Name:

  HGNC:4025

• Gene ID:

  5348

• UniProt:

  O00168

• Chromosomal Location:

  Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na (+) out of the cell and K (+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.

• Molecular Weight:

  10441

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FXYD1 Antibody (C-term) [APR32909G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5348

• Uniprot URL:

  https://www.uniprot.org/uniprot/O00168