Rabbit anti Human Calcium Channel
CAT:
579-X1515P
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Rabbit anti Human Calcium Channel
- Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.
- Synonyms: Voltage-Dependent L-Type Calcium Channel, beta3 subunit
- CAS Number: 9007-83-4
- UniProt: P54284
- Host: Rabbit
- Species Reactivity: Human
- Isotype: IgG
- Conjugation: Unconjugated
- Type: Polyclonal Antibody
- Applications: WB
- Field of Research: Signal Transduction
- Purification Method: Ammonium Sulfate Precipitation
- Assay Principle: This antibody can be used for Western blotting (5-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.
- Stability: See expiration date on vial
- Concentration: See vial for Concentration
- Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
- Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
- References & Citations: 1. Castellano,A.et.al., Cloning and expression of a third calcium channel beta subunit J. Biol. Chem. 268 (5), 3450-3455 (1993 2. Castellano,Aet.al. Cloning and expression of a neuronal calcium channel beta subunit J. Biol. Chem. 268 (17), 12359-12366 (1993) 3. Smith SM, et al.Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits.Ann N Y Acad Sci USA 868, 175-198 (1999)
- Shipping Conditions: Ambient Temperature, freeze upon arrival
- Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
- Functional Analysis: WB