Ac-Asp-Glu

Ac-Asp-Glu Catalog number: MDP0549 CAS Number: 134710-25-1 Sequence: Ac-Asp-Glu Amount: 10 mg Molecular Weight: 304 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: Subasinghe N, Schulte M, Chan MY, Roon RJ, Koerner JF, Johnson RL. Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase) J Med Chem. 1990 Oct;33(10):2734-44. 2: Ferrucci A, Leboffe L, Agamennone M, Di Pizio A, Fiocchetti M, Marino M, Ascenzi P, Luisi G. Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies Amino Acids. 2015 Jan;47(1):153-62. 3: Colantonio P, Leboffe L, Bolli A, Marino M, Ascenzi P, Luisi G. Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation Biochem Biophys Res Commun. 2008 Dec 19;377(3):757-62. 4: Shiah SG, Chuang SE, Kuo ML. Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells Mol Pharmacol. 2001 Feb;59(2):254-62. 5: Marino J, García Vior MC, Furmento VA, Blank VC, Awruch J, Roguin LP. Lysosomal and mitochondrial permeabilization mediates zinc(II) cationic phthalocyanine phototoxicity Int J Biochem Cell Biol. 2013 Nov;45(11):2553-62. 6: Liu X, Zhan W, Gao G, Jiang Q, Zhang X, Zhang H, Sun X, Han W, Wu FG, Liang G. Apoptosis-Amplified Assembly of Porphyrin Nanofiber Enhances Photodynamic Therapy of Oral Tumor J Am Chem Soc. 2023 Apr 12;145(14):7918-7930. 7: Kugawa F, Ueno A, Aoki M. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway Biol Pharm Bull. 2000 Aug;23(8):930-5. 8: Martin DJ, Rubenstein PA. Alternate pathways for removal of the class II actin initiator methionine J Biol Chem. 1987 May 5;262(13):6350-6. 9: Klusák V, Barinka C, Plechanovová A, Mlcochová P, Konvalinka J, Rulísek L, Lubkowski J. Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods Biochemistry. 2009 May 19;48(19):4126-38. 10: Murphy DJ, Walker B, Ryan CA, Martin SL. The inhibitor profiling of the caspase family of proteases using substrate-derived peptide glyoxals Biochem Biophys Res Commun. 2010 Nov 19;402(3):483-8.
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Catalog Number: MDP0549 (10 mg)

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