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Recombinant Staphylococcus aureus Staphylococcal complement inhibitor (scn)

CAT: 0399-CSB-EP416663SUK-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP416663SUK-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
(SCIN)
Abbreviation
Recombinant Staphylococcus aureus scn protein
Gene Name
Scn
UniProt
A7X482
Expression Region
32-116aa
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Target Sequence
STSLPTSNEYQNEKLANELKSLLDELNVNELATGSLNTYYKRTIKISGQKAMYALKSKDFKKMSEAKYQLQKIYNEIDEALKSKY
Tag
N-terminal 10xHis-tagged and C-terminal Myc-tagged
Type
In Stock Protein
Source
E.coli
Field of Research
Others
Relevance
Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses.
Endotoxin
Not test
Purity
Greater than 90% as determined by SDS-PAGE.
Activity
Not test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Molecular Weight
17.2 kDa
References & Citations
"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance." Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K. Antimicrob. Agents Chemother. 52:45-53 (2008) .
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Full Length of Mature Protein

UniProtKB · A7X482

Staphylococcal complement inhibitor

SCIN_STAA1 · Staphylococcus aureus (strain Mu3 / ATCC 700698)

View on UniProt ↗
Primary accession
A7X482
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
scn
Protein existence
3: Inferred from homology
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Taxonomy ID
418127
Alternative names
SCIN
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Cellular component

Secreted

Domain

Signal

Biological process

Virulence

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