Hamster Anti-Mouse CD152/CTLA-4-LE/AF

• Reactivity:

  Mouse

• Storage Conditions:

  The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added. Store at 2- 8 °C.
  The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 °C.
  With the exception of the low endotoxin, azide-free product, the vials should be stored at 2-8 °C. Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.

• Specificity:

  Mouse CD152/CTLA-4 costimulatory receptor, Mr 69 kDa
  CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28.^1,2 Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigenpresenting cells.^3 CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex.^1,3,4 Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.^1,5,6

• Short Name:

  [CD152/CTLA-4]

• CAS Number:

  9007-83-4