CD55 / Decay Accelerating Factor (DAF) Mouse Monoclonal Antibody

CD55 / Decay Accelerating Factor (DAF) Mouse Monoclonal Antibody

• CAS Number: 9007-83-4
• Gene Name: [CD55]
• NCBI Gene ID: 1604
• Reactivity: Human
• Storage Conditions: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a single chain glycoprotein of 70kDa, identified as CD55 (also known as decay accelerating factor, DAF). This MAb was clustered in Kobe at the Sixth International Workshop on Human Leukocyte Differentiation Antigens as F429D-9 (N-L120). CD55/DAF is widely expressed on cells throughout the body including leukocytes, erythrocytes, epithelium, endothelium, and fibroblasts. It is a Glycosyl phosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. It prevents the amplification steps of the complement cascade by interfering with the assembly of the C3-convertases, C4b2a and C3bBb, and the C5-convertase, C4b2a3b and C3bBb3b. CD55 also serves as receptor for CD97 and for echovirus and Coxsackie B virus. Anti-CD55 can be used as marker for paroxysmal nocturnal hemoglobinuria (PNH).
• Other Gene Names: [CD55; CD55; CR; TC; DAF; CROM; CR; DAF]
• Short Name: [CD55 / Decay Accelerating Factor (DAF)]
• Other Product Names: [complement decay-accelerating factor isoform 1 preproprotein; Complement decay-accelerating factor; complement decay-accelerating factor; CD55 molecule (Cromer blood group); CD_antigen: CD55]
• NCBI GI Number: 10835143
• NCBI Accession Number: NP_000565.1
• NCBI GB Accession Number: NM_000574.4
• Uniprot Accession Number: P08174