CD99 / MIC2 (Ewing's Sarcoma Marker) Mouse Monoclonal Antibody

CD99 / MIC2 (Ewing's Sarcoma Marker) Mouse Monoclonal Antibody

• CAS Number: 9007-83-4
• Gene Name: [CD99]
• NCBI Gene ID: 4267
• Reactivity: Human, Rat.
  Others not tested
• Storage Conditions: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a sialoglycoprotein of 27-32kDa, identified as CD99, or MIC2 gene product, or E2 antigen. MIC2 gene is located in the pseudo-autosomal region of the human X and Y chromosome. MIC2 gene encodes two distinct proteins, which are produced by alternative splicing of the CD99 gene transcript and are identified as bands of 30 and 32kDa (p30/32). Although its function is not fully understood, CD99 is implicated in various cellular processes including homotypic aggregation of T cells, upregulation of T cell receptor and MHS molecules, apoptosis of immature thymocytes and leukocyte diapedesis. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. Most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells express this antigen. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing's sarcoma cells and primitive peripheral neuroectodermal tumors. This MAb shows a very similar reactivity to other CD99 MAbs (e.g. O13, 12E7, or HBA-71) and is excellent for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues.
• Other Gene Names: [CD99; CD99; MIC2; HBA71; MIC2X; MIC2Y; MSK5X; MIC2; MIC2X; MIC2Y]
• Short Name: [CD99 / MIC2]
• Other Product Names: [CD99 antigen isoform b; CD99 antigen; CD99 antigen; CD99 molecule; 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; CD_antigen: CD99]
• NCBI GI Number: 171543879
• NCBI Accession Number: NP_001116370.1
• NCBI GB Accession Number: NM_001122898.2
• Uniprot Accession Number: P14209