CD46 (Membrane Cofactor Protein) Mouse Monoclonal Antibody

CD46 (Membrane Cofactor Protein) Mouse Monoclonal Antibody

• CAS Number: 9007-83-4
• Gene Name: [CD46]
• NCBI Gene ID: 4179
• Reactivity: Human
• Storage Conditions: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
• Other Gene Names: [CD46; CD46; MCP; TLX; AHUS2; MIC10; TRA2.10; MCP; MIC10]
• Short Name: [CD46]
• Other Product Names: [membrane cofactor protein isoform 1; Membrane cofactor protein; membrane cofactor protein; CD46 molecule; TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46]
• NCBI GI Number: 27502402
• NCBI Accession Number: NP_002380.3
• NCBI GB Accession Number: NM_002389.4
• Uniprot Accession Number: P15529