Ku (p70/p80)

• Gene Name:

  [XRCC6 (p70)]

• NCBI Gene ID:

  2547

• Reactivity:

  Human, Primates. Does not react with mouse, rat and chicken.

• Storage Conditions:

  Store at 2 to 8 °C. Antibody is stable for 24 months.

• Specificity:

  Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. MAb KU729 recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

• Other Gene Names:

  [XRCC6; XRCC6; ML8; KU70; TLAA; CTC75; CTCBF; G22P1; G22P1; 5'-dRP lyase Ku70; CTC75; CTCBF; Ku70; TLAA]

• Short Name:

  [Ku (p70/p80)]

• Other Product Names:

  [X-ray repair cross-complementing protein 6 isoform 1; X-ray repair cross-complementing protein 6; X-ray repair cross-complementing protein 6; 5'-dRP lyase Ku70; Ku autoantigen, 70kDa; DNA repair protein XRCC6; Ku autoantigen p70 subunit; 70 kDa subunit of Ku antigen; thyroid-lupus autoantigen p70; lupus Ku autoantigen protein p70; 5'-deoxyribose-5-phosphate lyase Ku70; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; thyroid autoantigen 70kD (Ku antigen); ATP-dependent DNA helicase 2 subunit 1; thyroid autoantigen 70kDa (Ku antigen); ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; X-ray repair complementing defective repair in Chinese hamster cells 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6]

• NCBI GI Number:

  573014815

• NCBI Accession Number:

  NP_001275905.1

• NCBI GB Accession Number:

  NM_001288976.1

• Uniprot Accession Number:

  P12956