Sheep Polyclonal (IgG) to Human Fibrinogen

Sheep Polyclonal (IgG) to Human Fibrinogen

• NCBI Gene ID: 280792
• Reactivity: Human
• Storage Conditions: Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles.
  Microcentrifugation recommended if solution contains precipitate.
• Specificity: Recognizes human fibrinogen, a complex ~340kD hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of alpha, beta and gamma chains linked by a series of 29 disulphide bonds. The six chains are arranged in such a way that all the N-Terminal ends adjoin to form a central with two trimeric coiled coil structures connecting to outer D domains. Fibrinogen plays an important role in the coagulation process with the D and E domains interacting via the C-Terminal ends of the alpha chains during fibrin clot cross-linking. Shows minimal cross-reactivity with related serum proteins. Fibrinogen has been identified as a ferritin binding protein in the horse. Has been successfully as a capture reagent for ferritin - anti ferritin IgG complexes in horse plasma to evaluate the antibody response to ferritin by ELISA.
• Other Gene Names: [FGG; FGG; Gamma']
• Short Name: [Fibrinogen]
• Other Product Names: [fibrinogen; Fibrinogen gamma-B chain; fibrinogen gamma-B chain; gamma'; fibrinogen, gamma polypeptide; fibrinogen gamma chain]
• NCBI GI Number: 350
• NCBI Accession Number: CAA33562.1
• Uniprot Accession Number: P12799