RABBIT ANTI CASPASE-7 (C-TERMINAL)

• NCBI Gene ID:

  840

• Reactivity:

  Mouse, Rat

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item recognises an epitope within the C-terminal region (CT) of Caspase-7, a 35kDa cysteine protease, otherwise known as ICE-like Apoptotic Protease 3 (ICE-LAP3).
  
  Caspase-7, a member of the ICE/Ced-3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase-7 occurs during cell death induced by the cytokine death receptors Fas/APO-1 and the receptor of tumour necrosis factor (TNFR-1), coupled with the fact that granzyme-B activated Caspase-7 cleaves the nuclear enzyme poly (ADP-ribose) polymerase (PARP), suggests an important role for Caspase-7 in both cytokine-mediated and Granzyme-B mediated apoptosis pathways.

• Other Gene Names:

  [CASP7; CASP7; MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3; MCH3; CASP-7; ICE-LAP3]

• Short Name:

  [CASPASE-7]

• Other Product Names:

  [caspase-7 isoform alpha; Caspase-7; caspase-7; ICE-like apoptotic protease 3; apoptotic protease MCH-3; caspase 7, apoptosis-related cysteine protease; caspase 7, apoptosis-related cysteine peptidase; Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3]

• NCBI GI Number:

  4502581

• NCBI Accession Number:

  NP_001218.1

• NCBI GB Accession Number:

  NM_001227.4

• Uniprot Accession Number:

  P55210

• CAS Number:

  9007-83-4