PML Polyclonal Antibody
CAT:
866-RD90235A-02
Size:
120 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PML Polyclonal Antibody
- Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
- Synonyms: MYL,PP8675,RNF71,TRIM19,PML
- Gene ID: 5371
- Swiss Prot: P29590
- Host: Rabbit
- Reactivity: Mouse,Rat
- Immunogen: A synthetic peptide of human PML
- Clonality: Polyclonal
- Isotype: IgG
- Conjugation: Unconjugated
- Applications: WB,IF
- Purification: Affinity purification
- Concentration: 1mg/mL
- Dilution: WB 1:500-1:2000,IF 1:50-1:200
- Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
- Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- Calculated Molecular Weight: 47-48kDa/62-97kDa
- Observed Molecular Weight: 67KDa