PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody

• Background:

  CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1) . This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

• Description:

  This is a PE/Cyanine7 Anti-Human CD274/PD-L1 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1

• Gene ID:

  29126

• Swiss Prot:

  Q9NZQ7

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Conjugation:

  PE/Cyanine7

• Type:

  Flow Cytometry Antibody

• Applications:

  FC

• Assay Type:

  Antibody

• Buffer:

  PBS with 0.05% Proclin300, 1% BSA

• Storage Conditions:

  Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

• Host or Source:

  Mouse

• Isotype:

  Mouse IgG2b, κ