Purified Anti-Mouse CD115 Antibody

• Background:

  CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

• Description:

  This is a Purified Anti-Mouse CD115 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor (EC:2.7.10.1), CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms, CD115, Csf1r, Csfmr, Fms

• Gene ID:

  12978

• Swiss Prot:

  P09581

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Type:

  Flow Cytometry Antibody

• Applications:

  FC

• Assay Type:

  Antibody

• Concentration:

  0.5 mg/mL

• Buffer:

  PBS with 0.05% Proclin300

• Storage Conditions:

  Store at 2~8°C. Do not freeze.

• Host or Source:

  Rat

• Isotype:

  Rat IgG2a, κ