Anti-Synaptogyrin 3/SYNGR3 Antibody Picoband®, APC Conjugate

• Background:

  Synaptogyrin 3 is a protein that in humans is encoded by the SYNGR3 gene. This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family.

• Description:

  Boster Bio Anti-Synaptogyrin 3/SYNGR3 Antibody Picoband® catalog # A14692-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Transmembrane protein 199; TMEM199; C17orf32

• Gene Name:

  transmembrane protein 199

• Gene ID:

  9143

• UniProt:

  O43761

• Host:

  Rabbit

• Reactivity:

  Human,Mouse,Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived human Synaptogyrin 3/SYNGR3 recombinant protein (Position: N45-Y229).

• Clonality:

  Polyclonal

• Tissue Specificity:

  Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

• Applications:

  WB,IHC,ELISA

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.

• Components:

  Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

• References & Citations:

  1. Kedra, D., Pan, H.-Q., Seroussi, E., Fransson, I., Guilbaud, C., Collins, J. E., Dunham, I., Blennow, E., Roe, B. A., Piehl, F., Dumanski, J. P. Characterization of the human synaptogyrin gene family. Hum. Genet. 103: 131-141, 1998.

• Storage Conditions:

  At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

• Calculated Molecular Weight:

  64099 MW

• Observed Molecular Weight:

  24 kDa

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.25-0.5 μg/ml, Mouse, Rat
  Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat
  ELISA, 0.1-0.5 μg/ml, -
  

• Subcellular Location:

  Endoplasmic reticulum membrane. Multi-pass membrane protein. COPI-coated vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein.

• Protein Name:

  DAP3 binding cell death enhancer 1