Anti-CaMKI beta/gamma/delta (Phospho Thr287) CAMK2B Monoclonal Antibody

• Description:

  Boster Bio Anti-CaMKI beta/gamma/delta (Phospho Thr287) CAMK2B Monoclonal Antibody catalog # M03964T287. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta;2.7.11.17; CAMK2B; CAM2, CAMK2, CAMKB;

• Gene Name:

  CAMK2B

• UniProt:

  Q13554

• Host:

  Mouse

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  Synthetic Peptide of CaMKIIβ/γ/δ (Phospho Thr287)

• Clonality:

  Monoclonal

• Clone:

  Clone: 4H2

• Tissue Specificity:

  Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

• Applications:

  IHC

• Purification:

  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  IHC 1:100-200

• Form:

  Liquid

• Function:

  Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+) /calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca (2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca (2+) transport and in fast-twitch muscle participates in the control of Ca (2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

• Molecular Weight:

  72678 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Calcium/calmodulin-dependent protein kinase type II subunit beta

• Subcellular Location:

  Cytoplasm, cytoskeleton

• Protein Name:

  Calcium/calmodulin-dependent protein kinase type II subunit beta