Anti-Stanniocalcin 1/STC/STC1 Antibody

• Background:

  STC1 (Stanniocalcin 1), also called STC, which is encoded by the STC1 gene. By fluorescence in situ hybridization, Chang et al. (1998) mapped the STC1 gene to chromosome 8p21-p11.2. Wagner et al. (1995) found evidence of STC immunoreactivity in human kidney and serum, suggesting the existence of the hormone in mammals. Zhang et al. (1998) reported a constitutive expression of STC in terminally differentiated neurons. Bell et al. (2001) determined that STC1 was 1 of several transcripts upregulated by umbilical vein endothelial cells during capillary morphogenesis in 3-dimensional collagen matrices.

• Description:

  Boster Bio Anti-Stanniocalcin 1/STC/STC1 Antibody Picoband® catalog # A03402. Tested in ELISA, IHC applications. This antibody reacts with Human.

• Synonyms:

  Interleukin-12 receptor subunit beta-1; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL-12 receptor beta component; CD212; IL12RB1; IL12R, IL12RB

• Gene Name:

  Interleukin-12 receptor subunit beta-1

• UniProt:

  P52823

• Host:

  Rabbit

• Reactivity:

  Human

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived human Stanniocalcin 1/STC/STC1 recombinant protein (Position: V34-A247) .

• Clonality:

  Polyclonal

• Applications:

  IHC, ELISA

• Field of Research:

  Cytokines, Immunology, Innate Immunity, Interleukins

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. .

• Storage Conditions:

  At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human
  ELISA, 0.1-0.5 μg/ml, -
  

• Other Gene Names:

  STC1

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Interleukin-12 receptor subunit beta-1