Recombinant Mouse Cathepsin D/CTSD Protein (His Tag)

Recombinant Mouse Cathepsin D/CTSD Protein (His Tag)

• Background: CTSD localizes to the lysosome and consists of a light chain and a heavy chain. CTSD is expressed in epithelial cells as well as in macrophages.CTSD is a lysosomal aspartyl protease that depends critically on protonation of its active site Asp residue and gets activated at pH 5 in endosome of hepatocytes. It has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix and xonnective tissue. In addition, CTSD has been used as a breast cancer tumor marker.
• Synonyms: CPSD, CTSD, Cathepsin D
• CAS Number: 9000-83-3
• UniProt: P18242
• Accession Number: NP_034113.1
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: Ile21-Leu410
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 56 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.