Recombinant Human Angiogenin/ANG Protein

• Background:

  Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin is associated with susceptibility to amyotrophic lateral sclerosis, which is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord.

• Abbreviation:

  Angiogenin; ANG

• Synonyms:

  ANG; Angiogenin; RNASE5; RNase 5; Ribonuclease 5

• UniProt:

  P03950

• Accession Number:

  P03950

• Expression System:

  E.coli

• Tag:

  None

• Sequence:

  Gln25-Pro147

• Field of Research:

  Signal Transduction; Cardiovascular; Cancer; epigenetics and nuclear signal; metabolism

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  14.3 kDa

• Observed Molecular Weight:

  14 kDa

• Species:

  Human